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 AccuPSYCH Report

 PGx Requisition



Identifying Optimal Drugs and Dosages Based on Genetics

Cutting Age Technology


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(800) 766-8378

Pharmacogenetic Testing (PGx)

Accu Reference Medical Lab offers an extensive pharmacogenetic test menu to help the clinician in identifying appropriate treatment and to monitor efficacy and toxicity by evaluating the genetic differences in metabolic pathways for each individual.

 

Gene Panels Available


AccuCARDIAC Panel

Genes tested: CYP2C19, CYP2D6, CYP2C9, CYP3A4, CYP3A5, SLCO1B1, APOE, VKORC1, LPA, ITGB3


AccuPSYCH Panel

Genes tested: CYP2C19, CYP2D6, CYP2C9, CYP3A4, CYP3A5, CYP1A2, ANKK1/DRD2, COMT, HTR2A, HTR2C, UGT2B15


AccuPAIN Panel

Genes tested: CYP2C19, CYP2D6, CYP2C9, CYP3A4, CYP3A5, CYP1A2, CYP2B6, OPRM1


AccuCOMPREHENSIVE Panel

Genes tested: CYP2C19, CYP2D6, CYP2C9, CYP3A4, CYP3A5, CYP1A2, CYP2B6, SLCO1B1, APOE, VKORC1, ANKK1/DRD2, OPRM1, COMT, HTR2B, LPA, ITGB3, UGT2B15


Other gene(s) tested:


CYP2C9/VKORC1

CYP2D6

CYP2C19


What are pharmacogenetic tests and why use them for patient testing? 

Pharmacogenetics is a field of research that seeks to understand genetic variability that leads to individual responses to medications. The long-term goal of pharmacogenetics is to help healthcare professionals (HCPs) select the drugs and dosages best suited for each person. By analyzing genes that produce specific drug targets, for example, a HCP may be able to adjust medication dosage for precision, optimizing efficacy and safety. The decision about which drug to prescribe may also be influenced by existing health contraindications or maintenance medications.


Pharmacogenetic testing is important in therapeutic decision-making. The Food and Drug Administration has begun including pharmacogenetic information on the labels of more than 150 medications, which can helps HCPS tailor their prescriptions to individual patients. Dosages and timing of therapies are usually based upon the anticipated metabolism and clearance rates of the average person, which is where pharmacogenetic testing comes in. Pharmacogenetic testing provides HCPs with the opportunity to personalize medication to best suit the individual. Being able to test patients for their response to a particular therapy helps provide efficacy and safety insight prior to starting the patient on a new therapeutic regime.

Pharmacogenetic Testing

Pharmacogenetic testing is only indicated currently for patients that may be taking or will begin taking a drug with an accepted pharmacogenetic test. However, pharmacogenetic testing may also be ordered when a medication with a narrow therapeutic range is selected, or one with a high rate of adverse events. Prior to commencing a patient on a particular therapy or after a patient has already begun a therapy (eg, during the initial phase of treatment or later in treatment) the accepted pharmacogenetic test can be carried out. Test results can then be combined with the existing patient history, clinical information and medication profile to personalize the therapeutic approach.

Personalized Treatment

Pharmacogenetic testing can also be a useful addition in the treatment decision-making process. This is because of how pharmacogenetic tests can provide both the HCP and patient with additional information for selecting a therapy and optimizing label-approved dosages. HCPs may use pharmacogenetic testing insight to adjust medication dosage or to switch therapeutic class, as examples. Single genes or multiple genes may be explored for expression patterns. An example of a therapy that requires multiple genes to be examined is warfarin because genetic variation in CYP2C9 and VKORC1 may affect its overall efficacy in the case of an excessive clotting disorder. Pharmacogenetic testing should only be used as a complementary approach for clinical and shared decision making, particularly with the aim to individualize dosing regimens, and to enhance drug efficacy and safety profiles within individuals.


Accureference offers pharmacogenetic tests that can provide data to aid clinicians in the therapeutic decision making process.


References:

1.    Pharmacogenetic tests. American Association for Clinical Chemistry. Website: https://labtestsonline.org/ understanding/analytes/ pharmacogenetic-tests/. Updated: April 3, 2014. Accessed: April 3, 2016.

2.    Pharmacogenetics fact sheet. National Institute of General Medical Sciences. Website: http://www.nigms.nih.gov/ education/Pages/ factsheet-pharmacogenomics.aspx. Updated: October 1, 2015. Accessed: April 3, 2016.

3.    Gervasini G et al. Pharmacogenetic testing and therapeutic drug monitoring are complementary tools for optimal individualization of drug therapy. Eur J Clin Pharmacol. 2010;66:755-774.

How to get PGx

Register your contact details and set up an account with us.


New Account Request (800) 766-8378

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Bayonne Patient Service Center #1
546 Ave C, Bayonne NJ 07002
Phone: (201) 471-7031
Hours: 7:30 AM - 5:00 PM
East Orange Patient Service Center
108 South Munn Ave, East Orange, NJ 07018
Phone: (862) 520-5315
Hours: 10:00 AM-5:00 PM
Florham Park Patient Service Center
15 James St, Florham Park, NJ 07932
Phone: (973) 301-1909
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359 N Main Street, Glassboro, NJ, 08028
Phone: (856) 881-5320
Hours: 7:30 AM-3:30 PM
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450 7th Street, Hoboken, NJ 07030
Phone: (201) 850-1437
Hours: 8:00 AM - 4:00 PM
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40 Union Avenue, Suite 205, Irvington, NJ 07111
Phone: (862) 231-6223
Hours: 9:00 AM - 7:00 PM
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709 Newark Ave 2nd Floor, Jersey City, NJ 07036
Phone: (201) 222-0178
Hours: 9:00 AM - 5:00 PM
Somerset Patient Service Center
1553 Rt.27, Somerset, NJ, 08873
Phone: (908)583-6645
Hours: 10:00 AM - 2:00 PM
Succasunna Patient Service Center
262 Route 10 West, Succasunna, NJ 07876
Phone: (973) 970-9314
Hours: 9:00 AM - 4:00 PM
Toms River Patient Service Center
508 Lakehurst Rd, Suite 3B, Toms River, NJ 08755
Phone: (732) 228-7528
Hours: 7:30 AM - 4:00 PM
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1030 St.Georges Avenue, Lower Level, Suite V, Avenel, NJ, 07001
Phone: (732) 326-2966
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Have questions or need assistance? Call (877) 733-4522
Have questions or need assistance? Call (877) 733-4522
Have questions or need assistance? Call (877) 733-4522
Have questions or need assistance? Call (877) 733-4522
Have questions or need assistance? Call (877) 733-4522
Have questions or need assistance? Call (877) 733-4522
Have questions or need assistance? Call (877) 733-4522
Have questions or need assistance? Call (877) 733-4522
Have questions or need assistance? Call (877) 733-4522
Have questions or need assistance? Call (877) 733-4522
Have questions or need assistance? Call (877) 733-4522
Have questions or need assistance? Call (877) 733-4522
Have questions or need assistance? Call (877) 733-4522
Have questions or need assistance? Call (877) 733-4522
Have questions or need assistance? Call (877) 733-4522
Have questions or need assistance? Call (877) 733-4522
Have questions or need assistance? Call (877) 733-4522
Have questions or need assistance? Call (877) 733-4522
Have questions or need assistance? Call (877) 733-4522
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1575 Hillside Avenue, Suite 100-A, New Hyde Park, New York, 11040
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66 Middlebush Rd. , Suite U300, Wappingers Falls, NY 12590
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970 N Broadway, Suite 301, Yonkers, NY
Phone: (914) 207-1295
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Bridgeport Patient Service Center
754 Clinton Avenue, Bridgeport, CT, 06108
Phone: (203) 290-4775
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Stamford Patient Service Center. 111 High Ridge Road, First Floor, Stamford, CT, 06905
Phone: (908) 583-6607
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Waterbury Patient Service Center
Waterbury Patient Service Center. 2247 E.Main Street, Suite 103, Waterbury, CT 06705
Phone: (203) 574-2030
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Athol Patient Service Center
1467 Main Street, Athol, MA 01331
Phone: (978) 249-3825
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Greenfield Patient Service Center
33 Riddell St, Greenfield, MA 01301
Phone: (413) 775-0000
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Lancaster Patient Service Center
136 High Street Ext, Lancaster, MA 01523
Phone: (978) 368-6352
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70 Pleasant Street, So Weymouth, MA, 02190
Phone: (908) 583-6610
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Cambridge Patient Service Center
10 Aurora Street, Cambridge, MD, 21613
Phone: (410) 228-0556
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Fayetteville Area Patient Service Center
905 Skibo Road, Suite 101, Fayetteville, NC, 28314
Phone: (910) 867-7071
Hours: 9:00 AM - 6:00 PM
Walter Reed Patient Service Center
1220 Walter Reed Road, Suite A, Fayetteville, NC, 28304
Phone: (910) 491-1956
Hours: 7:00 AM - 4:00 PM
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Bangor Patient Service Center
225 Erdman Avenue, Bangor, PA, 18013
Phone: (610) 452-9174
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101 South Church Street, Hazelton, PA 18704
Phone: (570) 455-0747
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King Of Prussia Patient Service Center
491 Allendale Road, Ste 106, Kings Of Prussia, PA, 19406
Phone: (484) 679-1278
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Kingston Patient Service Center
517 Pierce Street, Kingston, PA 18704
Phone: (570) 283-0674
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233 South Prospect Street, Nanticoke, PA, 18634
Phone: (570) 735-2626
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Conlin Patient Service Center
4420 Conlin Street, Ste#100, Metairie, LA, 70006
Phone: (504) 302-2035
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Lafayette Patient Service Center
850 Kaliste Saloom Road, Suite 111, Lafayette, LA, 70508
Phone: (337) 504-5926
Hours: 12:00 AM - 5:00 PM
Saxon Patient Service Center
4213 Saxon Street, Metairie, LA, 70006
Phone: (504) 779-8163
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