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Magnesium measurements are used in the diagnosis and treatment of hypomagnesemia (abnormally low) and hypermagnesemia (abnormally high).
Magnesium ions serve as activators for a number of important enzyme systems engaged in the transfer and hydrolysis of phosphate groups, such as hexokinase, alkaline phosphatase, prostatic acid phosphatase, and creatinine kinase.
Decreased serum magnesium levels have been observed in cases of diabetes, alcoholism, diuresis, hyperthyroidism, hypoparathyroidism, malabsorption, hyperalimentation, myocardial infarction, congestive heart failure and liver cirrhosis. Increased serum magnesium levels have been found in cases of renal failure, dehydration, severe diabetic acidosis and Addison’s Disease.
Magnesium procedure utilizes a direct method in which magnesium forms a colored complex with xylidyl blue in a strongly basic solution, where calcium interference is eliminated by glycoletherdiamine-N,N,N`,N`-tetraacetic acid (GEDTA). The color produced is measured bichromatically at 520/800 nm and is proportional to the magnesium concentration.
Collect: Serum Separator Tube (SST) - 0.5 ml serum.
Specimen preparation: Serum free from hemolysis is the recommended specimens. Allow blood samples to clot (15 mins). Separate the serum from the cells by centrifuging for 10 minutes. Store serum at 2-8°C until analysis.
Stability: Magnesium in serum is stable for one week when stored 2 to 8°C.
Accu Reference Medical Laboratory
Adults: 1.7 - 2.7 mg/dL
The assay Reportable Range is from 0.5 to 8.0 mg/dL. Samples exceeding the upper limit of linearity are diluted and repeated.