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Gastrointestinal Pathogen Panel (GPP), PCR

GPP

Same Day Results for 14 of the Most Common Causes of Infectious Diarrhea 

Improve patient outcomes, avoid needless isolation costs, and act fast to prevent outbreak situations with  xTAGฎ GPP.

From a single and simple laboratory test, you can get results for 14 of the most common causes of infectious gastroenteritis from a single stool sample in less than 5 hours. xTAG GPP is a qualitative multiplex test intended for the simultaneous detection and identification of nucleic acids from multiple gastroenteritis-causing viruses, bacteria and parasites (including toxin gene detection) in human stool samples.

This panel will replace traditional stool culture (STOCU) and the Giardia and Cryptosporidium antigen (OVPSC) screen.


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Methodology: Polymerase chain reaction (PCR)
Performed: Mon-Fri
Reported: 1-3 days
Specimen Required: Collect : Small amount of fecal material - 2 g. or 2 mL liquid stool. 

Specimen preparation: Place into screw top Sterile Container. Storage/Transport Temperature: Refrigerated 
Stability: Refrigerated : 48 hours, Frozen : 48 hours

NOTE: * This test is not available for New York patients, please refer to test code N630 for specimen requirements.*

Performing Laboratory
Accu Reference Medical Laboratory

CPT Code(s): 87507
Test Panel Components Detects gastrointestinal pathogen targets: Adenovirus (40/41), Campylobacter , Clostridium difficile toxin A/B, Cryptosporidium , Entamoeba histolytica, Escherichia coli O157, Enterotoxigenic Escherichia coli (ETEC) LT/ST, Giardia (G. lamblia), Norovirus GI/GII, Rotavirus A, Salmonella, Shiga Toxin-producing Escherichia coli (STEC) stx1/stx2, Shigella , Vibrio cholera.
PDF Document GPP Brochure.pdf
Sample Report
Additional Information


The benefits of GPP

1 Stool Sample, 1 Test, 14 Results—More results faster, enabling a higher diagnostic yield.

xTAG GPP offers the ability to non-invasively analyze patient stool samples for 14 GI pathogen targets simultaneously and at a much quicker processing time, as compared with conventional industry testing methods. 

- Superior sensitivity and specificity for detection of the most common enteric pathogens.

- Faster diagnosis of gastrointestinal infections with fewer tests and reduced costs.

- Co-infections determined by one multi-pathogen panel versus multiple tests.

Testing should be performed on individuals exhibiting signs and symptoms of gastrointestinal infection and to aid in the diagnosis of gastrointestinal infection when used in conjunction with clinical evaluation, laboratory findings, and epidemiological information. A gastrointestinal microorganism multiplex nucleic acid-based assay also aids in the detection and identification of acute gastroenteritis in the context of outbreaks (1).

xTAG GPP simultaneously detects 14 common viral, bacterial, and parasitic causative pathogens from a single patient sample:
•    Campylobacter
•    Clostridium difficile toxin A/B
•    Escherichia coli (E. coli) O157
•    Enterotoxigenic E. coli (ETEC) LT/ST
•    Salmonella
•    Shigella
•    Shiga-like Toxin producing E. coli (STEC) stx 1/stx 2
•    Vibrio cholerae, cholera toxin gene (ctx)
•    Adenovirus 40/41
•    Norovirus
•    Rotavirus A
•    Cryptosporidium
•    Entamoeba histolytica
•    Giardia

This test is not recommended for in-patients hospitalized for more than 3 days.

Procedure 

The target is amplified using polymerase chain reaction (PCR) or reverse transcription PCR, then analyzed with Luminex xTAG technology to detect the presence or absence of each pathogen in the panel. The test has been cleared or approved for diagnostic use by the U.S. Food and Drug Administration for fecal specimens. 

Disclaimer

Information derived from Gastrointestinal Pathogen Panel Package Insert (Luminex Corporation). Gastrointestinal Pathogen Panel is a product of Luminex Corporation. xTAG is a registered trademark of Luminex Corporation. Luminex is a registered trademark of Luminex Corporation.


USING GPP  IN YOUR CLINICAL PRACTICE

Test Overview

• Non-invasive stool test

• Outstanding accuracy

• Helps decrease and contain outbreaks of highly contagious gastrointestinal infections

• Turn-around time of just 24 hours!

• Helps reduce over-prescription of antibiotics

• Provide better patient care

• Patients return specimens to th lab directly via FedEX

• Widely covered by major insurances


When should the testing be ordered?

• Persistent or chronic diarrhea

• Bloody diarrhea

• Diarrhea in association with systemic illness

• Immunocompromised status

• Returned traveler

• Hospitalized patient

• Outbreak identification


In healthcare settings and in specific populations (newborns/infants, elderly or immunocompromised patients), these infections are potentially serious. Rapid diagnosis is important for appropriate treatment and infection control measures.

References

  1. Luminex xTAG GPP Gastrointestinal Pathogen Panel

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