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Cystic Fibrosis (CF) Profile, 97 Mutations, CFplus®
|Methodology:||DNA is isolated from the sample and tested for the 97 CF mutations listed. Regions of the CFTR gene are amplified enzymatically and subjected to a solution-phase multiplex allele-specific primer extension with subsequent hybridization to a bead array and fluorescence detection. Some mutations are then specifically identified by bidirectional dideoxysequencing.|
Collect: Lavender-top (EDTA) tube - 7 ml.
Specimen Preparation: Transport Whole Blood in original tube.
Storage/Transport Temperature: Room temperature OR Refrigerate at 4°C.Causes for Rejection: Frozen or hemolyzed specimen; quantity not sufficient for analysis; one buccal swab; improper container; wet buccal swab.
Note: This test is approved for NY .
LabCorp Laboratory Corporation of America
|Test Panel Components||Testing for 97 cystic fibrosis mutations, including all of the mutations currently recommended by the ACMG and ACOG|