Laboratory Test DirectoryShare
BRCA 1 & BRCA 2 Sequencing and Deletion/Duplication. Breast and Ovarian Hereditary Cancer Panel
BRCAThe BRCA gene test is a blood test that uses DNA analysis to identify harmful changes (mutations) in either one of the two breast cancer susceptibility genes — BRCA1 and BRCA2.
|Methodology:||Next Generation Sequencing|
Collect: Lavender (EDTA) - 2.0 ml whole blood OR Buccal Swab
Specimen Preparation: For the Buccal Swab Collection Instruction see Attached File.
Storage/Transport Temperature: Send Original LAV Tube OR Buccal Swab.
Maintain specimen at room temperature.
Causes for Rejection: Frozen whole blood, serum, or marrow; leaking tube; clotted blood or marrow; grossly hemolyzed specimen; incorrect anticoagulant
Comment: Patient Genetic History Form/Patient Consent Form is require. See Attached File.
Stability: Room Temperature: 72 hours, Refrigerated: 1 week
NOTE: * This test is not available for New York patients, please refer to test code L911 for specimen requirements.*
Lincoln Diagnostics LLC
|CPT Code(s):||81211, 81213|
|PDF Document||BUCCAL SWAB COLLECTION.pdf|
A diagnosis of Hereditary Breast and Ovarian Cancer Syndrome (HBOC) is considered when there are multiple cases of breast cancer and/or ovarian cancer on the same side of the family.
Which patients should be tested for BRCA1 and BRCA2 mutations?
- Breast cancer diagnosed at age 50 or younger
- Ovarian cancer at any age
- Multiple primary breast cancers either in the same breast or opposite breasts
- Both breast and ovarian cancer
- Triple-negative breast cancer
- Pancreatic cancer with breast or ovarian cancer in the same individual or on the same side of the family
- Ashkenazi Jewish ancestry
- Two or more relatives with breast cancer, one under age 50
- Three or more relatives with breast cancer at any Age